Lee's big break came in 1995 with the lead role in writer-director Kevin Smith's comedy Mallrats, in which he deftly portrayed the inconsiderate slacker Brodie. Lee then went on to star in Smith's Chasing Amy (for which he won an Independent Spirit Award for Best Supporting Male for his role as Banky) and as the demonic "Azrael" in Smith's supernatural comedy Dogma. He reunited with Smith in the Dimension Films comedy Jay and Silent Bob Strike Back and had a cameo role in Smith's Clerks II.

Lee co-starred in Cameron Crowe's Golden Globe-winning ensemble feature Almost Famous, in the role of "Jeff Bebe," the lead singer of a 1970s rock band called Stillwater. He then re-teamed with Crowe on the writer-director's film Vanilla Sky.

After working with director Lawrence Kasdan in the ensemble comedy Mumford, Lee reunited with Kasdan for the director's suspense thriller, Dreamcatcher.

Lee's additional film credits include writer-director Rebecca Miller's feature, The Ballad of Jack and Rose (with Daniel Day-Lewis and Catherine Keener), director Barry Sonnenfeld's ensemble comedy Big Trouble, as well as Enemy of the State and Kissing a Fool.

He co-starred as the voice of "Syndrome" in Walt Disney Pictures and Pixar's Academy Award-winning animated feature The Incredibles, and he also voiced a character in Sony's "motion-capture" feature Monster House, about three teenagers who discover their neighbor's house is a monster.

Jason Lee not only stars, but also serves as a producer on My Name Is Earl, and has been recognized with a Golden Globe nomination for Best Actor in a Television Series and a SAG nomination for Outstanding Performance by a Male Actor for his portrayal of Earl.

Jason also wrote and directed the silent love story, The White Door, which stars Giovanni Ribisi and Beth Riesgraf.

Lee is a photographer, as well as an avid supporter and collector of the arts. He is also actively involved with his skateboard company, Stereo Skateboards. In his leisure, he enjoys spending time playing guitar, writing and recording music, and listening to his classical and jazz favorites.