More recently, Boreanaz starred opposite Anne Heche in Alan Cumming's independent black comedy, Suffering Man's Charity.

Boreanaz was exposed to the television business at a young age as the son of a veteran weather forecaster for WPVI in Philadelphia. He moved to Los Angeles to try his luck in Hollywood after graduating from Ithaca College. He got his first break with a guest spot on Married...with Children, in which he played the biker boyfriend of "Kelly Bundy" (Christina Applegate).

On stage, Boreanaz has performed at the Ensemble Theatre in Hat Full of Rain and at the Gardner Stage in Italian-American Reconciliation and Fool for Love. He has also performed on theater row in Cowboy Mouth.