If you took a moment to get to know Betty Suarez (America Ferrera), you'd see how sweet, intelligent and hard-working she is. But few people do, because in the world of high fashion Betty is the oversized peg in the petite round hole. When publishing mogul Bradford Meade (Alan Dale) hands the reigns of Mode, the bible of the fashion industry, over to his son, Daniel, he specifically hires Betty as his son's new assistant - mostly because she's the only woman in NYC Daniel won't sleep with. Though this "player" is reluctant to accept her at first, Betty's indomitable spirit and bright ideas will eventually win him over. Neither of them really knows the ins and outs of the fashion world, but the two are a formidable team against those who will do anything to see them fall.

And they really are swimming with the sharks. Diva fashionista Wilhelmina Slater (Vanessa Williams)is incensed that Bradford Meade passed her over and promoted Daniel (Eric Mabius) to the coveted job after the mysterious death (or was it?) of Mode's legendary editor, Fey Sommers. Wilhelmina, along with toadying assistant Marc and scheming receptionist Amanda (Becki Newton), are out to sabotage Daniel and Betty any chance they get. Betty finds a friend in warm-hearted Christina (Ashley Jensen), who works as the magazine's in-house seamstress and seems to know everything about everybody who works there.

Away from work, Betty's home life is far from glamorous. Dad Ignacio (Tony Plana)and her sister, Hilda (Ana Oritz), worry that she's just setting herself up for a fall, while nephew Justin encourages his aunt to dream big (even if he's aghast at her fashion sense). Nerdy boyfriend Walter, who unceremoniously dumped Betty, keeps turning up despite her attempts to get him to stay away.

Ugly Betty stars America Ferrera as Betty Suarez, Eric Mabius as Daniel Meade, Alan Dale as Bradford Meade, Tony Plana as Ignacio, Ana Ortiz as Hilda, Ashley Jensen as Christina, Becki Newton as Amanda, Mark Indelicato as Justin and Vanessa Williams as Wilhelmina Slater. Recurring guest stars are Michael Urie as Marc and Kevin Sussman as Walter.

Based on Yo Soy Betty La Fea, the groundbreaking Colombian telenovela that became an international phenomenon. Academy Award nominee and Emmy Award winner Salma Hayek is executive producer, along with Silvio Horta (Urban Legends), Ben Silverman, (The Office), Jose Tamez (The Maldonado Miracle), James Parriott (Grey's Anatomy) and James Hayman (Joan of Arcadia).